In "Quantico" (2015-2018), a TV series where Priyanka played the lead role of Alex Parrish, her character's romantic relationships were a significant part of the storyline. Her character's on-again, off-again relationship with her co-star, Ryan McPartlin, was a central plot point.

Priyanka's relationship with American singer and actor, Nick Jonas, in 2016, marked a significant milestone in her personal life. The couple got engaged in July 2018 and married in a lavish ceremony in Jodhpur, India, in December 2018. They also had a second wedding ceremony in New York City, which was more intimate. However, in 2019, the couple announced their separation and filed for divorce, which was finalized in 2020.

One of her earliest and most notable relationships was with her co-star, Shah Rukh Khan, during the filming of "Kaminey" in 2009. Although the relationship reportedly ended due to their busy schedules and personal differences, it marked one of the initial high-profile relationships in her career.